ChemicalBook CAS DataBase List 1-Adamantaneacetic acid

1-Adamantaneacetic acid synthesis

6synthesis methods

Product Name:1-Adamantaneacetic acid
CAS Number:4942-47-6
Molecular formula:C12H18O2
Molecular Weight:194.27

27174-71-6
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144-55-8 Synthesis

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4942-47-6
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$6.00/1g

Yield:4942-47-6 93%

Reaction Conditions:

with hydrogenchloride;sodium hydroxide in methanol

Steps:

R.10 Referential Example 10
Referential Example 10 Production of 2-adamantyl acetic acid: 2.5N sodium hydroxide 433 ml was added to methanol 1125 ml solution of 2-adamantyl acetic acid methyl ester 150 g (0.72 mole) and stirred at room temperature for 6 hours. The reaction mixture was concentrated in vacuo, and aqueous sodium bicarbonate was added to the residue and the mixture was washed with ether. Aqueous layer was adjusted to pH I by adding 12N hydrochloric acid and extracted with ethylacetate. The extract was dried by anhydrous sodium sulfate. After removing the drying agent by filtration, the filtrate was concentrated in vacuo to obtain the product. Yield: 129.39 g (Yield 93%)

References:

Asahi Kasei Kogyo Kabushiki Kaisha US5658923, 1997, A

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