1-CHLORO-2-(4-NITROPHENYL)ETHANE synthesis
- Product Name:1-CHLORO-2-(4-NITROPHENYL)ETHANE
- CAS Number:20264-95-3
- Molecular formula:C8H8ClNO2
- Molecular Weight:185.61
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Yield: 30%
Reaction Conditions:
with nitric acid at 0; for 0.75 h;
Steps:
171 Example 171; 8-[2-(4-benzo[d]isoxazol-3-yl-piperazin-1-yl)-ethyl]-3,5-dihydro-1H-furo[3,4-c]quinolin-4-one
To 1-chloro-2-phenylethane (20 g, 0.14 mol) at 0 C was added fuming nitric acid (20 ml) dropwise. The mixture was stirred at the same temperature for an additional 45 min. The reaction was quenched cautiously with water (200 mL). It was extracted with dichloromethane (100 mL), dried over MgSO4, and crystallized from chloroform/hexane to obtain 2 (8.0 g, 30 %).1H NMR (400 MHz, CDCl3) δ 8.20 (d, 2H), 7.40 (d, 2H), 3.75 (t, 2H), 3.20 (t, 2H)
References:
WARNER-LAMBERT COMPANY LLC WO2004/26864, 2004, A1 Location in patent:Page 132; 133
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