Hexadecanamide, N-3-(hexadecyloxy)-2-hydroxypropyl-N-(2-hydroxyethyl)- synthesis
- Product Name:Hexadecanamide, N-3-(hexadecyloxy)-2-hydroxypropyl-N-(2-hydroxyethyl)-
- CAS Number:110483-07-3
- Molecular formula:C37H75NO4
- Molecular Weight:598
![2-Propanol, 1-(hexadecyloxy)-3-[(2-hydroxyethyl)amino]-](/CAS/20200331/GIF/67780-92-1.gif)
Yield: 55%
Reaction Conditions:
with potassium hydroxide in ethanol at 80; for 3 h;
Steps:
1.2; 2.2 Step 3
Take all the above crude secondary amine derivatives B and add KOH 10mmol (0.561g)Add to a round bottom flask, then add 100 mL of ethanol, and stir to dissolve at 80°C;Subsequently, the ethanol was distilled off under reduced pressure. Increase the temperature to 80°C again, slowly add 120mmol (32.400g) of methyl palmitate dropwise under reduced pressure, and the drop will be completed in about 3 hours;The reaction was continued for 6 hours, and the reaction was stopped. Recrystallization of n-hexane/ethanol to obtain Ceramide E,The total yield is 55%, and the purity is 98%.
References:
CN112321445, 2021, A Location in patent:Paragraph 0016; 0041; 0044-0045; 0048
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