Ethanone, 1-[2-hydroxy-3-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-4,6-dimethoxyphenyl]- synthesis

3synthesis methods

Product Name:Ethanone, 1-[2-hydroxy-3-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-4,6-dimethoxyphenyl]-
CAS Number:113225-21-1
Molecular formula:C16H23NO5
Molecular Weight:309.3575

3-PIPERIDINONE, 1-METHYL-4-(2,4,6-TRIMETHOXYPHENYL)-

113225-10-8
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$36.00/250mg

Ethanone, 1-[2-hydroxy-3-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-4,6-dimethoxyphenyl]-

113225-21-1
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Yield:-

Steps:

Multi-step reaction with 3 steps
1.1: 76 percent / dibenzoyl-D-tartaric acid / methanol / 25 - 85 °C
2.1: 56 percent / DIBAL-H / CH₂Cl₂ / 3.5 h / -78 °C
3.1: BF₃*Et₂O / CH₂Cl₂ / 20 °C
3.2: 82.6 percent / 20percent aq. KOH / methanol / 48 h

References:

Kim;Sack;Tokarski;Qian;Chao;Leith;Kelly;Misra;Hunt;Kimball;Humphreys;Wautlet;Mulheron;Webster [Journal of Medicinal Chemistry,2000,vol. 43,# 22,p. 4126 - 4134]

108-24-7
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$14.00/250ML

113225-19-7 Synthesis

3-PIPERIDINOL, 1-METHYL-4-(2,4,6-TRIMETHOXYPHENYL)-, (3S,4R)-

113225-19-7
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113225-21-1
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References

(R)-N-METHYL-3-OXO-4-(2',4',6'-TRIMETHOXY) PIPERIDINE

205506-14-5
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113225-21-1
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References