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Ethanone, 2,2,2-trifluoro-1-[4-(1-methylethyl)phenyl]- (9CI) synthesis

5synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 3 steps
1: tetrabutyl ammonium fluoride / tetrahydrofuran; N,N-dimethyl-formamide / 6 h / 20 °C / Inert atmosphere; Cooling with ice
2: tetrabutyl ammonium fluoride / tetrahydrofuran; water / 0 - 20 °C / Inert atmosphere
3: Dess-Martin periodane; sodium carbonate / dichloromethane / 3 h / 20 °C

References:

Fang, Zhongxue;Gong, Yanmei;Liu, Binbin;Zhang, Jin;Han, Xinyue;Liu, Zhaohong;Ning, Yongquan [Organic Letters,2022,vol. 24,# 48,p. 8920 - 8924]

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