(2E)-1-(3-methoxyphenyl)-3-(thiophen-2-yl)prop-2-en-1-one synthesis

Yield:1287790-77-5 91%

Reaction Conditions:

with sodium hydroxide in ethanol;water; for 4 h;Cooling with ice;Aldol Condensation;

Steps:

Preparation of the Chalcones

General procedure: An Illustrative Procedure with (E)-1-Aryl-3-(2-pyrrolyl)-2-propenones (3k). 2-Pyrrolecarbaldehyde (12 mmol), acetophenone (13 mmol), and 24 mmol of NaOH in ethanol (20 mL) and water (10 mL) were mixed in an ice-bath and stirred for 4 h in the bath. The mixture was neutralized with 1 M-HCl aqueous solution to pH 8-9. The resulting precipitate was collected and recrystallized from ethanol.

References:

Jeong, Eun Jeong;Lee, In-Sook Han [Bulletin of the Korean Chemical Society,2019,vol. 40,# 7,p. 668 - 673]