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ChemicalBook CAS DataBase List 1,2-Benzisothiazole, 6-Bromo-2,3-Dihydro-, 1,1-Dioxide

1,2-Benzisothiazole, 6-Bromo-2,3-Dihydro-, 1,1-Dioxide synthesis

2synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 2 steps
1.1: N-Bromosuccinimide / acetonitrile / 0.08 h / 90 °C
1.2: 1.33 h / 90 °C
2.1: sodium hydrogencarbonate / acetonitrile / 24 h / 90 °C / Inert atmosphere

References:

UCB BIOPHARMA SPRL;BRACE, Gareth Neil;CHOVATIA, Prafulkumar Tulshibhai;FOULKES, Gregory;JOHNSON, James Andrew;JONES, Severine Danielle;KROEPLIEN, Boris;LECOMTE, Fabien Claude;LOKE, Pui Leng;LOWE, Martin Alexander;MANDAL, Ajay;NORMAN, Timothy John;PALMER, Christopher Francis;PÉREZ-FUERTES, Yolanda;PORTER, John Robert;SMYTH, Donald;TRANI, Giancarlo;UDDIN, Muhammed;ZHU, Zhaoning WO2016/198400, 2016, A1

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