ChemicalBook CAS DataBase List 1H-INDOLE, 2-METHYL-6-(TRIFLUOROMETHOXY)-

1H-INDOLE, 2-METHYL-6-(TRIFLUOROMETHOXY)- synthesis

3synthesis methods

Product Name:1H-INDOLE, 2-METHYL-6-(TRIFLUOROMETHOXY)-
CAS Number:57330-49-1
Molecular formula:C10H8F3NO
Molecular Weight:215.17

57330-59-3 Synthesis

2-Nitro-1-(2-oxopropyl)-4-trifluoromethoxybenzene

57330-59-3
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$224.00/1g

1H-INDOLE, 2-METHYL-6-(TRIFLUOROMETHOXY)-

57330-49-1
20 suppliers
$65.00/10mg

Yield:57330-49-1 93%

Reaction Conditions:

with 5% Pd(II)/C(eggshell);hydrogen at 0 - 60; under 3102.97 Torr; for 7 h;Large scale reaction;Leimgruber-Batcho-type cyclization;

References:

Maligres, Peter E.;Humphrey, Guy R.;Marcoux, Jean-Francois;Hillier, Michael C.;Zhao, Dalian;Krska, Shane;Grabowski, Edward J.J. [Organic Process Research and Development,2009,vol. 13,# 3,p. 525 - 534] Location in patent:experimental part

Benzoic acid, 2-[[2-methyl-6-(trifluoromethoxy)-1H-indol-3-yl]thio]-

637042-30-9
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57330-49-1
20 suppliers
$65.00/10mg

References

Acetamide, 2,2,2-trifluoro-N-[2-(1-propyn-1-yl)-5-(trifluoromethoxy)phenyl]-

1139688-65-5
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57330-49-1
20 suppliers
$65.00/10mg

References