1H-Indole-3-carbonylchloride,1-methyl-(9CI) synthesis

10synthesis methods

Product Name:1H-Indole-3-carbonylchloride,1-methyl-(9CI)
CAS Number:126921-19-5
Molecular formula:C10H8ClNO
Molecular Weight:193.63

32387-21-6
204 suppliers
$8.00/1g

1H-Indole-3-carbonylchloride,1-methyl-(9CI)

126921-19-5
20 suppliers
$248.00/1g

Yield:126921-19-5 100%

Reaction Conditions:

with thionyl chloride in N,N-dimethyl-formamide at 20; for 3 h;

Steps:

13 Example 13: Preparation of N-methyl-2-((3-((E)-2-(2-pyridyl)vinyl)-1-(1-methyl-1H-indole-3-formyloxy)methyl-1H-indazol-6-yl)thio)benzamide (compound 13)

_{Add to the reaction flask 1-Methyl-1H-indole-3-carboxylic acid (378.3mg, 2.16mmol, 1.0eq.), Thionyl chloride (1.55 g, 12.96 mmol, 6.0 eq.) and DMF (0.05 mL). The reaction mixture was stirred at room temperature for 3 hours. Then directly concentrate the reaction mixture, 1-Methyl-1H-indole-3-carboxylic acid chloride (418.24 mg, 100%) was obtained.}

References:

CN112442010,2021,A Location in patent:Paragraph 0135-0136