ChemicalBook CAS DataBase List 1H-Pyrrolo[2,3-b]pyridin-4-amine, 1-methyl-

1H-Pyrrolo[2,3-b]pyridin-4-amine, 1-methyl- synthesis

2synthesis methods

Product Name:1H-Pyrrolo[2,3-b]pyridin-4-amine, 1-methyl-
CAS Number:869335-48-8
Molecular formula:C8H9N3
Molecular Weight:147.18

1H-Pyrrolo[2,3-b]pyridine, 1-methyl-4-nitro-

869335-47-7
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1H-Pyrrolo[2,3-b]pyridin-4-amine, 1-methyl-

869335-48-8
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Yield:869335-48-8 99%

Reaction Conditions:

with hydrogen;acetic acid in methanol; for 3 h;

Steps:

16 Preparation Example 16 Preparation of 1-methyl-1H-pyrrolo[2,3-b]pyridin-4-amine

1-methyl-4-nitro-1H-pyrrolo[2,3-b]pyridine obtained in Preparation Example 15(175 mg, 0.99 mmol) was dissolved in methanol (10 ml),Acetic acid (3 ml), Raney nickel(Raney Ni, catalytic amount) was added and stirred under hydrogen gas for 3 hours. After completion of the reaction,After filtration through celite, the filtrate was neutralized with sodium hydroxide (2N) and extracted with ethyl acetate (100 ml).The organic layer was dried over anhydrous sodium sulfate (Na2SO4), concentrated under reduced pressure, and the residue was subjected to silica gel column chromatography.(Normal hexane and ethyl acetate, 1/5, v/v); to obtain the title compound (160 mg, 99%).

References:

KR101508214,2015,B1 Location in patent:Paragraph 0238-0242

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869335-48-8
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$100.00/25mg

References