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ChemicalBook CAS DataBase List 2-(2-METHYLPHENYL)PYRROLIDINE

2-(2-METHYLPHENYL)PYRROLIDINE synthesis

5synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 3 steps
1: sodium hydride / tetrahydrofuran / 3 h / Heating
2: hydrogenchloride / tetrahydrofuran; water / Reflux
3: acetic acid; sodium tetrahydroborate / methanol / 20 °C / Cooling with ice

References:

Wang, Junwei;Song, Qiao;Xu, Anhua;Bao, Yu;Xu, Yungen;Zhu, Qihua [European Journal of Medicinal Chemistry,2017,vol. 130,p. 15 - 25]

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