2,3-Butanoquinazoline-4(3H)-one synthesis

11synthesis methods

Product Name:2,3-Butanoquinazoline-4(3H)-one
CAS Number:2446-62-0
Molecular formula:C12H12N2O
Molecular Weight:200.24

Benzamide, 2-[(5-chloro-1-oxopentyl)amino]-

107954-46-1
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2446-62-0
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Yield:2446-62-0 92%

Reaction Conditions:

with potassium tert-butylate in tetrahydrofuran at 20;Inert atmosphere;

Steps:

Synthesis of 2,3-dihydropyrrolo[1,2-a]quinazolin-5(1H)-ones: general procedure B

General procedure: Toasolutionoftheappropriatesubstituted2-(4-chlorobutanamido)-benzamidessubstrate(1.0eq)inTHF(10mLpermmolsubstrate)wasaddedtBuOK(2.0eq).ThereactionwasstirredatroomtemperatureuntilTLCindicatedcompletion,thensolventwasremovedinvacuo,theresultingresiduere-dissolvedinCH2Cl2(20mL)andNaHCO3(15mL),andtheaqueouslayerextractedwithCH2Cl2(520mL).ThecombinedorganicphasesweredriedoverMgSO4andsolventremovedinvacuo.TheproductswereobtainedafterpurificationoftheresiduebyFCC.

References:

Sutherell, Charlotte L.;Ley, Steven V. [Synthesis,2017,vol. 49,# 1,art. no. SS-2016-Z0435-OP,p. 135 - 144] Location in patent:supporting information