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2,3-dimethyl-1H-indene synthesis

13synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 3 steps
1.1: lithium diisopropyl amide / tetrahydrofuran / 2 h / -78 °C / Inert atmosphere
1.2: -78 - 20 °C / Inert atmosphere
2.1: tetrahydrofuran / 20 °C / Inert atmosphere
3.1: toluene-4-sulfonic acid / benzene / 90 °C / Inert atmosphere

References:

Dai, Yun;Feng, Xiangqing;Du, Haifeng [Organic Letters,2019,vol. 21,# 17,p. 6884 - 6887]