ChemicalBook CAS DataBase List 2,3-dimethyl-5-nitropyridine

2,3-dimethyl-5-nitropyridine synthesis

3synthesis methods

Product Name:2,3-dimethyl-5-nitropyridine
CAS Number:89244-47-3
Molecular formula:C7H8N2O2
Molecular Weight:152.15

583-61-9 Synthesis

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Yield:89244-47-3 37.83 g (53%)

Reaction Conditions:

with sulfuric acid;potassium nitrate

Steps:

Synthesis of Compound 10

Synthesis of Compound 10 Fuming sulfuric acid (500 g, 5.1 mol) was added slowly to 2,4-lutidine 8 (55 mL, 0.48 mol) and cooled in an ice bath with stirring. Potassium nitrate (87.5 g, 0.86 mol) was then added slowly. The reaction mixture was stirred at room temperature for 1 h and then allowed to warm to 110° C. for additional 7 h, cooled to room temperature and stirred overnight. The reaction mixture was poured onto ice (1.0 kg) and neutralized to pH 9 with solid NaOH, extracted with ether. The combined extracts were dried over anhydrous Na₂ SO₄. The solvent was removed and the residue was distilled under reduced pressure to give 37.83 g (53%) of a mixture of 3-nitrolutidine 10 and 5-nitrolutidine 9. Further separation by distillation provided pure 3-nitrolutidine 10. ¹ H NMR (CDCl₃) δ 2.35 (s, 3H), 2.57 (s, 3H), 7.13 (d, 1 H, J=4.8 Hz), 8.46 (d, 1 H, J=5.0 Hz).

References:

US5869676,1999,A

583-61-9 Synthesis

583-61-9
342 suppliers
$5.00/5g

89244-47-3
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References