ChemicalBook CAS DataBase List 2-(4-bromophenyl)-4,6-diphenyl-1,3,5-triazine

2-(4-bromophenyl)-4,6-diphenyl-1,3,5-triazine synthesis

6synthesis methods

Product Name:2-(4-bromophenyl)-4,6-diphenyl-1,3,5-triazine
CAS Number:23449-08-3
Molecular formula:C21H14BrN3
Molecular Weight:388.26

2-(4-bromophenyl)-4,6-diphenyl-1,3,5-triazine can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory organic synthesis and chemical and pharmaceutical research and development process. Its synthesis method is 4-Bromo-N-benzylideneaniline and benzamidine were dissolved in chloroform. The mixture was heated to 80 ℃ for 24 h and filtered to obtain 2-(4-bromophenyl)-4,6-diphenyl-1,3,5-triazine (colorless needles).

3842-55-5 Synthesis

3842-55-5
307 suppliers
$6.00/1g

5467-74-3
454 suppliers
$8.00/1g

2-(4-bromophenyl)-4,6-diphenyl-1,3,5-triazine

23449-08-3
210 suppliers
$6.00/250mg

Yield:23449-08-3 96%

Reaction Conditions:

with tetrakis(triphenylphosphine) palladium⁽⁰⁾;potassium carbonate in tetrahydrofuran;water at 80; for 12 h;Inert atmosphere;

Steps:

32 Synthesis Example 32: Synthesis of Intermediate I-32

Synthesis Example 32: Synthesis of Intermediate I-32 The compound, 2-chloro-4,6-diphenyl-1,3,5-triazine (50 g, 187 mmol) was dissolved in THF (1 L) under a nitrogen environment, (4-bromophenyl)boronic acid (45 g, 224.12 mmol, Aldrich Corporation), and tetrakis(triphenylphosphine)palladium (2.1 g, 1.87 mmol) were added thereto, and the mixture was stirred. Potassium carbonate saturated in water (64 g, 467 mmol) was added thereto, and the obtained mixture was heated and refluxed at 80° C. for 12 hours. When the reaction was complete, water was added to the reaction solution, and the mixture was extracted with dichloromethane (DCM) and then, filtered after removing moisture with anhydrous MgSO₄and concentrated under a reduced pressure. This obtained residue was separated and purified through flash column chromatography to obtain Compound I-32 (70 g and 96%). HRMS (70 eV, EI+): m/z calcd for C₂₁H₁₄BrN₃: 387.0371. found: 387. Elemental Analysis: C, 65%; H, 4%

References:

US2017/331067,2017,A1 Location in patent:Paragraph 0260-0263