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2-(4-CHLOROPHENYL)-1,3,4-OXADIAZOLE synthesis

12synthesis methods
-

Yield:23289-10-3 100%

Reaction Conditions:

Stage #1: ethyl 5-(4-chlorophenyl)-1,3,4-oxadiazole-2-carboxylatewith lithium hydroxide in tetrahydrofuran;water at 20;Inert atmosphere;
Stage #2: with hydrogenchloride in water at 20; pH=1 - 2;Inert atmosphere;

References:

Aurelio, Luigi;Scullino, Carmen V.;Pitman, Melissa R.;Sexton, Anna;Oliver, Victoria;Davies, Lorena;Rebello, Richard J.;Furic, Luc;Creek, Darren J.;Pitson, Stuart M.;Flynn, Bernard L. [Journal of Medicinal Chemistry,2016,vol. 59,# 3,p. 965 - 984]

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