ChemicalBook CAS DataBase List 2,4-DICHLORO-6-METHYLNICOTINIC ACID

2,4-DICHLORO-6-METHYLNICOTINIC ACID synthesis

2synthesis methods

Product Name:2,4-DICHLORO-6-METHYLNICOTINIC ACID
CAS Number:56022-07-2
Molecular formula:C7H5Cl2NO2
Molecular Weight:206.03

ETHYL 2,4-DICHLORO-6-METHYLPYRIDINE-3-CARBOXYLATE

86129-63-7
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56022-07-2
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$162.63/250mg

Yield:56022-07-2 66%

Reaction Conditions:

Stage #1: ethyl 2,4-dichloro-6-methylpyridine-3-carboxylatewith sodium hydroxide in methanol;water at 80; for 4 h;
Stage #2: with sulfuric acid in methanol;water;

Steps:

2,4-dichloro-6-methylnicotinic acid

2,4-dichloro-6-methylnicotinic acid A solution of commercially available (Maybridge) ethyl 2,4-dichloro-6-methylpyridine-3-carboxylate (1.0 g, 4.3 mmol) and NaOH (342 mg, 8.6 mmol) in water (1.7 mL) and MeOH (1.5 mL) was heated to 80° C. for 4 h. The mixture was acidified using 50% H₂SO₄ and filtered. The solid was washed with cold water and dried to give of 2,4-dichloro-6-methylpyridine-3-carboxylic acid (582 mg, 66%): LCMS RT: 0.70 min, MH⁺: 206.2.

References:

US6677352,2004,B1 Location in patent:Page/Page column 60; 85

3-Pyridinecarboxylic acid, 1,4-dihydro-2-hydroxy-6-methyl-4-oxo-, ethyl ester

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56022-07-2
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$162.63/250mg

References

2,4-DICHLORO-6-METHYLNICOTINIC ACID Related Search:

2,4-Dichloropyridine-3-carboxylic acid 2,4-DICHLORO-6-METHYLNICOTINALDEHYDE 2,4-DICHLORO-3,6-DIMETHYLPYRIDINE 2,4-Dichloro-6-picoline 2-Chloro-6-methylnicotinic acid 6-Methylnicotinic acid