2,4-Dihydro-5-isopropyl-2-methyl-3H-pyrazol-3-one synthesis
- Product Name:2,4-Dihydro-5-isopropyl-2-methyl-3H-pyrazol-3-one
- CAS Number:31272-05-6
- Molecular formula:C7H12N2O
- Molecular Weight:140.18
Yield:31272-05-6 100%
Reaction Conditions:
in tetrahydrofuran;ethanol at 0; for 36 h;Inert atmosphere;Reflux;
Steps:
Intermediate 12
To a solution of isopropyl 3-oxohexanoate (12.11 g, 76.6 mmol) in anhydrous ethanol (150 mL) was added dropwise a solution of methylhydrazine (4.0 mL, 76.6 mmol) in THF (1 N) at 0 °C. The reaction was allowed to be warmed up to room temperature and stirred for 28 hrs. The mixture was further heated under reflux for 8 hrs. Reaction mixture was concentrated on rotavapor to dryness to provide intermediate 12 as an orange solid (10.72 g, 100%).1H NMR (400 MHz, DMSO-d6) δ (ppm): 10.70 (s, 1H), 5.10 (s, 1H), 3.36 (s, 3H), 2.65-2.61 (m, 1H), 1.07 (t, J = 7.2 Hz, 6H). MS (ESI): Calcd for C7H13N2O: 141.1, found: 141.2 (M+H)+.
References:
WO2016/205460,2016,A1 Location in patent:Paragraph 0156-0157
80866-47-3
1 suppliers
inquiry
60-34-4
2 suppliers
$65.59/25g
143706-72-3
0 suppliers
inquiry
31272-05-6
12 suppliers
inquiry
598-23-2
64 suppliers
$55.00/1g
31272-05-6
12 suppliers
inquiry
