2-(4-PYRIDINYL)-1,3,5-TRIAZINE synthesis
- Product Name:2-(4-PYRIDINYL)-1,3,5-TRIAZINE
- CAS Number:68847-44-9
- Molecular formula:C8H6N4
- Molecular Weight:158.16
Yield:68847-44-9 77%
Reaction Conditions:
with sodium methylate;sodium in methanol;water;N,N-dimethyl-formamide;
Steps:
1.a (a)
(a) 2-(4'-Pyridyl)-s-triazine 1.0 g of sodium and then 104 g of 4-cyanopyridine (1 mole) are dissolved at room temperature in 500 ml of absolute methanol and the solution is subsequently stirred for 6 hours at 25°-30° C. Then 162 g of sodium methylate (3 moles) and a solution of 240 g of formamidine hydrochloride (3 moles) in 500 ml of absolute dimethyl formamide are added at 25°-30° C. After the reaction mixture has been stirred for 16 hours at 25°-30° C., it is refluxed for 6 hours at 100° C. bath temperature. After it has cooled, the mixture is concentrated by rotary evaporation and the residue is diluted with 4 liters of water. The precipitate is collected with suction and the filter residue is washed with water and dried in vacuo at 80° C., giving 121.4 g of 2-(4'-pyridyl)-s-triazine (77% of theory) with a melting point of 189°-191° C.
References:
US4116675,1978,A
6313-33-3
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