(2,5-DICHLORO-4-PYRIDINYL)METHANOL synthesis
- Product Name:(2,5-DICHLORO-4-PYRIDINYL)METHANOL
- CAS Number:866039-42-1
- Molecular formula:C6H5Cl2NO
- Molecular Weight:178.02
88912-26-9
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$6.00/1g
866039-42-1
32 suppliers
$221.00/500mg
Yield:866039-42-1 81%
Reaction Conditions:
with borane-THF in tetrahydrofuran at 0 - 20; for 2.5 h;
Steps:
184.1 Step 1: Preparation of (2,5-dichloropyridin-4-yl)methanol
A solution of 2,5-dichloropyridine-4-carboxylic acid (2.00 g, 10.417 mmol, 1.0 equiv) and BH3-THF (30 mL, 3.0 equiv, 1 mol/L in THF) in tetrahydrofuran (100 mL) was stuffed for 30 mm at 0°C and 2 h at room temperature. The reaction was then quenched by water, extracted ethyl acetate, washed with brine and concentrated under vacuum. The residue was purified by a silica gel column eluting with ethyl acetate/petroleum ether (1:3) to afford the title compound (1.5 g, 81%) as a white solid.
References:
WO2015/52264,2015,A1 Location in patent:Paragraph 01981; 01982
623585-74-0
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866039-42-1
32 suppliers
$221.00/500mg