ChemicalBook CAS DataBase List 2,5-Dichlorobenzooxazole

2,5-Dichlorobenzooxazole synthesis

8synthesis methods

Product Name:2,5-Dichlorobenzooxazole
CAS Number:3621-81-6
Molecular formula:C7H3Cl2NO
Molecular Weight:188.01

22876-19-3 Synthesis

22876-19-3
149 suppliers
$13.00/5g

3621-81-6
167 suppliers
$8.00/1g

Yield:3621-81-6 91%

Reaction Conditions:

with thionyl chloride;N,N-dimethyl-formamide in dichloromethane at 5 - 20; for 4 h;

Steps:

1.3 Step 3: Synthesis of 2,5-dichlorobenzoxazole.
Thionyl chloride (885 g, 7.5 mol)And N, N-dimethylformamide (270 ml) were added to a solution of 5-chloro-2-mercaptobenzoxazole (540 g, 2.903 mol) in dichloromethane (5 L) at 5-10 ° C.Stirred until a clear solution was formed and the reaction solution was stirred at room temperature for 4 hours.After completion of the reaction, the reaction solution was poured into 4 L of ice water, neutralized to neutral with sodium bicarbonate in 1 hour, and extracted with dichloromethane (2.5 L * 2).The organic layer was washed with brine, dried over sodium sulfate and dried to give the crude product. The crude product was washed with n-hexane (2 L * 2) at -20 ° C, filtered and dried to give yellow liquid 2,5-dichlorobenzo (496.8 g, 91.0%).

References:

Shanghai ZaiQi Bio-Tech Co., Ltd.;Wang, Zhiguo;Song, Yanhong;Ma, Xiujuan;Tian, Beibei;Li, Shijiang;Li, Chao;Li, Qiang;Li, Tao CN106478537, 2017, A Location in patent:Paragraph 0027; 0028; 0039; 0040; 0050; 0051; 0065; 0066

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95-85-2 Synthesis