ChemicalBook CAS DataBase List 2,5-Difluorophenol

2,5-Difluorophenol synthesis

6synthesis methods

Product Name:2,5-Difluorophenol
CAS Number:2713-31-7
Molecular formula:C6H4F2O
Molecular Weight:130.09

446-17-3 Synthesis

446-17-3
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2713-31-7
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$5.00/1g

Yield:2713-31-7 94.1%

Reaction Conditions:

with water;sodium hydroxide at 80 - 155; for 35 h;Sealed tube;

Steps:

11 Example 11
Add 630 grams of water and 95 grams of sodium hydroxide to a 1-liter pressure-resistant reactor, and stir at room temperature.Add 70 grams of 2,4,5-trifluorobenzoic acid, seal the reaction kettle, heat up to 80-85°C for 20 hours to keep the reaction, and heat up to 150-155°C to continue the reaction for 15 hours, and stop the reaction.The reaction system was lowered to room temperature, the reaction solution was taken out, adjusted to pH 1-2 with concentrated hydrochloric acid, and extracted with isopropyl acetate.The organic phases were combined, dried, concentrated, and rectified to obtain 48.66 g of 2,5-difluorophenol with a yield of 94.1% and a purity of 99.4%.

References:

CN112479825, 2021, A Location in patent:Paragraph 0041-0042

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372-20-3 Synthesis