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2-acetaMido-4-chloro-5-Methylbenzoic acid synthesis

4synthesis methods
201230-82-2 Synthesis
carbon monoxide

201230-82-2
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2-acetaMido-4-chloro-5-Methylbenzoic acid

1204312-39-9
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Yield:1204312-39-9 83%

Reaction Conditions:

with Pd(OTf)2(MeCN)4;water;toluene-4-sulfonic acid;p-benzoquinone in 1,4-dioxane at 20 - 80; under 760.051 Torr;

References:

Giri, Ramesh;Lam, Jonathan K.;Yu, Jin-Quan [Journal of the American Chemical Society,2010,vol. 132,# 2,p. 686 - 693] Location in patent:supporting information; experimental part