ChemicalBook CAS DataBase List 2-Acetyl-5-bromothiophene

2-Acetyl-5-bromothiophene synthesis

10synthesis methods

Product Name:2-Acetyl-5-bromothiophene
CAS Number:5370-25-2
Molecular formula:C6H5BrOS
Molecular Weight:205.07

1003-09-4 Synthesis

1003-09-4
465 suppliers
$10.00/25g

75-36-5 Synthesis

75-36-5
559 suppliers
$17.92/100G

5370-25-2
268 suppliers
$8.00/5g

Yield:5370-25-2 86.1%

Reaction Conditions:

in dichloromethane

Steps:

R.1 2-Acetyl-5-bromothiophene (b-1) STR41
REFERENTIAL EXAMPLE 1 2-Acetyl-5-bromothiophene (b-1) STR41 When 1.56 ml (1.1 equivalents) of acetyl chloride was added to a solution of 3.26 g (0.02 mmol) of 2-bromothiophene in 30 ml of CH₂ Cl₂, the mixture foamed and turned black. After stirring for 1 hr. at room temperature, the mixture was mixed with ice and concentrated hydrochloric acid. While being decolored with active carbon, the mixture was extracted with CH₂ Cl₂, whereby 3.53 g (Yield: 86.1%) of the objective product, 2-acetyl-5-bromothiophene (b-1) was obtained as colorless crystals.

References:

Shinogi & Co., Ltd. US4839365, 1989, A

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