2-Bromo-4-(difluoromethoxy)aniline synthesis

Yield:1000574-79-7 93%

Reaction Conditions:

with N-Bromosuccinimide in dichloromethane; for 3 h;Reflux;

Steps:

4 Example 4 Synthesis of 4-difluoromethoxy-2-bromoaniline by bromination

In a 250-mI four-necked flask equipped with a mechanical stirrer, a constant-pressure dropping funnel, a reflux condenser, and a thermometer, add 16 g of 4-difluoromethoxyaniline and 100 mL of dichloromethane.18 g of N-bromosuccinimide (NBS) was dissolved in 100 mL of dichloromethane, and the N-bromosuccinimide (NBS) solution was dropped into the 4-difluoromethoxyaniline solution while stirring at room temperature.Stir at reflux for 3 h. Thin-layer chromatography (TLC, dichloromethane: methanol volume ratio 3: 1) is followed to the end of the reaction. The reaction solution is concentrated to remove the organic solvent.That is, 4-difluoromethoxy-2-bromoaniline was obtained as a light-colored powdery solid product with a yield of 93% and a purity of 95%.

References:

CN110590576,2019,A Location in patent:Paragraph 0009