2-Bromo-4-thiazolecarboxylic acid synthesis
- Product Name:2-Bromo-4-thiazolecarboxylic acid
- CAS Number:5198-88-9
- Molecular formula:C4H2BrNO2S
- Molecular Weight:208.03
100367-77-9
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5198-88-9
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Yield:5198-88-9 93%
Reaction Conditions:
with methanol;sodium hydroxide at 0; for 2 h;
Steps:
410 Intermediate 410B: 2-bromothiazole-4-carboxylic acid
To a solution of ethyl 2-bromothiazole-4-carboxylate (10.5 g, 44.5 mmol) in methanol (150 mL) was added 10% NaOH (45 mL, 44.5 mmol) dropwise at 0 °C. The reaction mixture was stirred at 0 °C for 2 h. The reaction mass was concentrated under vacuum to remove volatiles, aqueous layer was acidified with 1.5 N HC1 to pH 4-5, the solid precipitated was filtered and dried to get 2-bromothiazole-4-carboxylic acid (8.7 g, 41.4 mmol, 93 % yield) as a white solid product. LCMS retention time 0.33 min [C]. MS (E-) m/z: 208.0 (M+2H).
References:
BRISTOL-MYERS SQUIBB COMPANY WO2021/67326, 2021, A1 Location in patent:Page/Page column 212-213
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5198-88-9
223 suppliers
$8.00/250mg
100367-77-9
258 suppliers
$5.00/250mg
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5198-88-9
223 suppliers
$8.00/250mg