2-broMo-N-Methyl-N-(4-nitrophenyl)acetaMide synthesis
- Product Name:2-broMo-N-Methyl-N-(4-nitrophenyl)acetaMide
- CAS Number:23543-31-9
- Molecular formula:C9H9BrN2O3
- Molecular Weight:273.08
Yield:23543-31-9 48%
Reaction Conditions:
with triethylamine in dichloromethane at 0 - 20; for 20 h;
Steps:
4.1. General procedure A. Synthesis of a-bromoanilides 9a-i.
General procedure: To a stirred solution of the aniline 7 and triethylamine (1 equiv)in CH2Cl2 (~0.9 mM) at 0 °C was added acid bromide 8 (1 equiv) in CH2Cl2 (~0.6 M) via cannula. The solution was allowed to warm to rt and stirred for 20 h. Further CH2Cl2 was added and the organics washed with 10% HCl solution, brine, dried (MgSO4) and concentrated in vacuo to afford the title compounds 9a-i which could be used without further purification.
References:
Gorman, Ryan M.;Hurst, Timothy E.;Petersen, Wade F.;Taylor, Richard J.K. [Tetrahedron,2019,vol. 75,# 49,art. no. 130711]
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