ChemicalBook CAS DataBase List 2-Chloro-3,5-dinitrobenzoic acid

2-Chloro-3,5-dinitrobenzoic acid synthesis

5synthesis methods

Product Name:2-Chloro-3,5-dinitrobenzoic acid
CAS Number:2497-91-8
Molecular formula:C7H3ClN2O6
Molecular Weight:246.56

118-91-2 Synthesis

118-91-2
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$8.50/5g

2497-91-8
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$23.89/25g

Yield: 73.5%

Reaction Conditions:

with fuming sulphuric acid;sulfuric acid;nitric acid at 0 - 125; for 7 h;

Steps:

2 Preparation of intermediate 2a 2-chloro-3,5-dinitrobenzoic acid
2-chlorobenzoic acid (7.8 g, 50 mmol) was dissolved in 25 mL of concentrated sulfuric acid.Stir until completely dissolved,Cool in ice bath to 0 ° C, Slowly add 15 mL of fuming nitric acid to the reaction system. After 30 minutes, Continue to stir at 0 ° C for 0.5 hours. Then the temperature was raised to 125 ° C and the reaction was stirred for 6 hours. Add 250 mL of ice water to the reaction system. Precipitate in white, filter, wash, dryDrying, the intermediate 2-chloro-3,5-dinitrobenzoic acid 2a, The yellow solid was 9.04 g, and the yield was 73.5%.

References:

Chinese Academy Of Medical Sciences Pharmaceutical Institute;Huang Haihong;Zhang Xinwei;Yin Dali CN104211708, 2018, B Location in patent:Paragraph 0117-0120

609-99-4 Synthesis