ChemicalBook CAS DataBase List 2-CHLORO-3-NITRO-5-(TRIFLUOROMETHYL)PYRIDINE

2-CHLORO-3-NITRO-5-(TRIFLUOROMETHYL)PYRIDINE synthesis

8synthesis methods

Product Name:2-CHLORO-3-NITRO-5-(TRIFLUOROMETHYL)PYRIDINE
CAS Number:72587-15-6
Molecular formula:C6H2ClF3N2O2
Molecular Weight:226.54

56-93-9 Synthesis

56-93-9
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$5.00/25g

33252-64-1 Synthesis

2-HYDROXY-5-NITRO-3-(TRIFLUOROMETHYL)PYRIDINE

33252-64-1
158 suppliers
$10.00/250mg

2-CHLORO-3-NITRO-5-(TRIFLUOROMETHYL)PYRIDINE

72587-15-6
157 suppliers
$29.71/1g

Yield:72587-15-6 92%

Reaction Conditions:

with trichlorophosphate in acetonitrile; for 3 h;Heating;

Steps:

22.a

a) Synthesis of 2-chloro-3-nitro-5-trifluoromethyl-pyridine In a 25 ml flask, 3-nitro-5-trifluoromethyl-pyridin-2-ol (300 mg, 1.44 mmol) was dissolved in acetonitrile (4.5 ml), and then phosphorus oxychloride (0.4 ml, 4.33 mmol) and benzyltrimethyl ammonium chloride (164 mg, 0.721 mmol) were added thereto. The mixture was stirred for 3 hours at 800. After completion of the reaction, water was added thereto and the mixture was extracted with ethyl acetate. The combined organic layer was dried over anhydrous sodium sulfate (Na₂SO₄), filtered and evaporated under reduced pressure to obtain white solid (300 mg, 92%). ¹H-NMR (DMSO-d₆, 300 MHz); δ=9.21 (s, 1H), 9.08 (s, 1H).

References:

US2011/28467,2011,A1 Location in patent:Page/Page column 22

33252-64-1 Synthesis

33252-64-1
158 suppliers
$10.00/250mg

72587-15-6
157 suppliers
$29.71/1g

References