ChemicalBook CAS DataBase List 2-Chloro-4-fluoro-5-nitrophenol

2-Chloro-4-fluoro-5-nitrophenol synthesis

5synthesis methods

Product Name:2-Chloro-4-fluoro-5-nitrophenol
CAS Number:84478-75-1
Molecular formula:C6H3ClFNO3
Molecular Weight:191.54

2-chloro-4-fluoro-5-nitrophenyl ethyl carbonate

153471-75-1
21 suppliers
$490.00/1g

84478-75-1
194 suppliers
$10.00/1g

Yield:84478-75-1 98%

Reaction Conditions:

with water;sodium hydrogencarbonate in methanol at 20; for 16 h;

Steps:

47.47C
To a solution of the product from Example 47B (0.87 g, 3.30 mmol) in methanol (20 mL) and water (1 mL) was added sodium bicarbonate (2.22 g, 26.4 mmol) and the mixture stirred at room temperature for 16 hours. The methanol was then removed under vacuum, dichloromethane (20 mL) was added to the mixture, the organic solution was washed with brine (50 mL), dried over anhydrous magnesium sulfate, filtered, and concentrated under vacuum to provide the title product (0.62 g, 98%).

References:

ABBOTT LABORATORIES WO2008/133753, 2008, A2 Location in patent:Page/Page column 88

FullText

84478-89-7 Synthesis