2-CHLORO-4-FLUOROBENZYL ALCOHOL synthesis
- Product Name:2-CHLORO-4-FLUOROBENZYL ALCOHOL
- CAS Number:208186-84-9
- Molecular formula:C7H6ClFO
- Molecular Weight:160.57
2252-51-9
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$7.00/5g
208186-84-9
128 suppliers
$17.00/5g
Yield: 91.3%
Reaction Conditions:
with borane-THF in tetrahydrofuran at 0 - 20; for 2 h;
Steps:
8.1 (2-chloro-4-fluorophenyl)methanol
2-Chloro-4-fluorobenzoic acid 4a (5.0 g, 28.7 mmol) was dissolved in 50 mL of tetrahydrofuran, and borane tetrahydrofuran solution (86.2 mL, 86.2 mmol, 1 M/THF) was added dropwise at 0 ° C, and reacted at room temperature for 2 hours. . At 0 ° C, 50 mL of 10% sodium hydroxide solution was added to quench the reaction. The organic layer was washed with saturated sodium chloride (50 mL). Methanol 8a (4.2 g, white solid), yield: 91.3%.
References:
Zhejiang Haizheng Pharmaceutical Co., Ltd.;Guan Dongliang;Wang Zhongli;Bai Hua;Liu Zhubo;Meng Lichen;Zhao Weifeng;Ling Long;Wang Yan CN109574927, 2019, A Location in patent:Paragraph 0359; 0362-0365
84194-36-5
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$9.00/1g
208186-84-9
128 suppliers
$17.00/5g
85953-29-3
173 suppliers
$6.00/1g
208186-84-9
128 suppliers
$17.00/5g