2-HYDRAZINO-6-(TRIFLUOROMETHYL)PYRIDINE synthesis
- Product Name:2-HYDRAZINO-6-(TRIFLUOROMETHYL)PYRIDINE
- CAS Number:94239-06-2
- Molecular formula:C6H6F3N3
- Molecular Weight:177.13
39890-95-4
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Yield:94239-06-2 99.4%
Reaction Conditions:
with hydrazine hydrate in ethanol at 80; for 14 h;
Steps:
32
[0628] to a solution of compound 59a (10 g, 55.08 mmol) in EtOH (30 ml) was added NH2NH2.H2O (32 ml, 550.80 mmol). After addition, the reaction mixture was stirred at 80 °C for 14 hrs. The reaction mixture was concentrated and the residue was dissolved into 150 ml of EtOAc, the mixture was washed with water (50 ml) and brine (50 ml), then dried over Na2SO4 and concentrated in vacuum to afford compound 59b (9.7 g, yield 99.4%) as white solid. 1H NMR (400mhz, DMSO-d6) δ 8.02 (s, 1h), 7.71 - 7.53 (m, 1h), 7.03-6.79 (m, 2h), 4.23 (s, 2h).
References:
WO2018/64119,2018,A1 Location in patent:Paragraph 0628
![6-(Trifluoromethyl)tetrazolo[1,5-a]pyridine](/CAS/20180601/GIF/143812-60-6.gif)
143812-60-6
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94239-06-2
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1513-65-1
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