ChemicalBook CAS DataBase List 2'-HYDROXY-4',6'-DIMETHOXYACETOPHENONE

2'-HYDROXY-4',6'-DIMETHOXYACETOPHENONE synthesis

13synthesis methods

Product Name:2'-HYDROXY-4',6'-DIMETHOXYACETOPHENONE
CAS Number:90-24-4
Molecular formula:C10H12O4
Molecular Weight:196.2

Preparation by reaction of acetonitrile on phloroglucinol dimethyl ether (Hoesch reaction).

480-66-0 Synthesis

2',4',6'-Trihydroxyacetophenone monohydrate

480-66-0
344 suppliers
$10.00/1g

77-78-1
287 suppliers
$19.69/1ml

90-24-4
255 suppliers
$29.00/10mg

Yield:90-24-4 100%

Reaction Conditions:

with potassium carbonate in acetone for 3 h;Reflux;

Steps:

To a refluxing solution of 2,4,6-trihydroacetophenone-monohydrate (10 g, 53.7 mmol) and K₂CO₃ (15 g, 108.7 mmol) in acetone (150 mL), (CH₃)₂SO₄ was added at three hour intervals (3 x 3.5 mL, 40.0 mmol). The solution was filtered and the solvent was evaporated to afford 2,4-dimethoxy-6-hydroxyacetophenone as a yellow solid (98%).

References:

UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC.;UNIVERSIDAD PERUMA CAYETANO HEREDIA;INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT (IRD);THE JOHNS HOPKINS UNIVERSITY;HAMMOND, Gerald, B.;APONTE, Jose, C.;GILMAN, Robert, H.;SAUVAIN, Michel, Henri-Auguste;VAISBERG, Abraham WO2010/19861, 2010, A1 Location in patent:Page/Page column 38; 50

FullText