ChemicalBook CAS DataBase List 2-HYDROXYTETRAHYDROPYRAN

2-HYDROXYTETRAHYDROPYRAN synthesis

11synthesis methods

Product Name:2-HYDROXYTETRAHYDROPYRAN
CAS Number:694-54-2
Molecular formula:C5H10O2
Molecular Weight:102.13

4221-03-8
80 suppliers
$14.00/100mg

694-54-2
78 suppliers
$16.00/1g

Yield:694-54-2 95 g

Reaction Conditions:

with hydrogenchloride in chloroform at 70; for 2 h;Temperature;

Steps:

1.1; 2.1; 3.1; 4.1 1) Preparation of 2-hydroxytetrahydropyran
Add 105g of 5-hydroxyvaleraldehyde and 200mL of chloroform into the three-necked flask, while continuously introducing anhydrous hydrogen chloride gas, heating to 70°C and reacting for 2h; The product after the reaction was distilled under reduced pressure, and the fraction with the mother liquor temperature of 50°C to 70°C was collected under a pressure of 300Pa. Obtain 95 g of 2-hydroxytetrahydropyran as a colorless transparent viscous oily product.

References:

Dongguan Bodun Flavors Co., Ltd.;Cai Guoxiang;Zhong Nengbang;Guan Junjian;Wu Qilin;Hu Shilin;Feng Jiao CN111303101, 2020, A Location in patent:Paragraph 0079-0125

110-87-2 Synthesis