ChemicalBook CAS DataBase List 2-Methylpyrimidine

2-Methylpyrimidine synthesis

13synthesis methods

Product Name:2-Methylpyrimidine
CAS Number:5053-43-0
Molecular formula:C5H6N2
Molecular Weight:94.11

1780-26-3 Synthesis

1780-26-3
464 suppliers
$10.00/10g

5053-43-0
159 suppliers
$60.00/250mg

Yield:5053-43-0 28%

Reaction Conditions:

with palladium 10% on activated carbon;hydrogen;magnesium oxide in methanol;water at 20; under 1551.49 Torr; for 1 h;

Steps:

113.2 Step 2: 2-methylpyrimidine .
To a solution of 4,6-dichloro-2-methyl-pyrimidine (240 g, 1.47 mol) in methanol (1.32 1) and H₂0 (1.10 1) were added 10 % Pd/C (240 g) and MgO (240 g, 5.95 mol). The RM was stirred at rt under H₂ atmosphere (30 psi) for 1 h. The mixture was filtered through Celite. The filtrate was extracted with DCM (4 x 1 1). The combined organic phases were distilled to remove DCM at 39 °C and methanol at 65 °C under 1 atm of pressure to give the title compound as a brown liquid. Y = 28 %. ^.H NMR (400 MHz, methanol-) δ 8.66 (d, J= 5 Hz, 2H), 7.29 (t, J= 5 Hz, 1H), 2.65 (s, 3H).

References:

NODTHERA LIMITED;BOCK, Mark G.;WATT, Alan Paul;PORTER, Roderick Alan;HARRISON, David WO2019/25467, 2019, A1 Location in patent:Paragraph 0694

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124-42-5 Synthesis