ChemicalBook CAS DataBase List 2-methylquinolin-3-ol

2-methylquinolin-3-ol synthesis

9synthesis methods

Product Name:2-methylquinolin-3-ol
CAS Number:613-19-4
Molecular formula:C10H9NO
Molecular Weight:159.18

2-methylquinolin-3-ol was prepared by o-aminobenzaldehyde condensed with chloroacetone.

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Yield: 96.4%

Reaction Conditions:

with tetrabutylammomium bromide;water;sodium hydroxide in tetrahydrofuran at 30;Reagent/catalyst;Temperature;

Steps:

1-9 Example 8
1) The first solution is prepared by dissolving o-aminobenzaldehyde, chloroacetone and tetrabutylammonium bromide in tetrahydrofuran; and the second solution is prepared by dissolving sodium hydroxide and zinc oxide in water. Then, the first solution and the second solution are mixed to obtain a mixed solution. Among them, the mass ratio of o-aminobenzaldehyde, chloroacetone, tetrabutylammonium bromide, sodium hydroxide and zinc oxide in the mixed solution is 1:0.75:0.10:0.75:0.10. The pH value of the mixed solution = 12.3. 2) Pump the mixed solution obtained in step 1) into a preheater to preheat to 30°C to obtain a preheated reaction solution; then pump the preheated reaction solution into a microchannel reactor and heat it at 30°C for reaction, wherein The flow rate of the mixed solution is 66 mL/min; the product obtained by the reaction enters the separation tank for separation treatment to obtain 2-methyl-3-hydroxy-quinoline. 3) Calculate the yield of 2-methyl-3-hydroxy-quinoline obtained in step 2) is 96.4%.

References:

Hunan Xin Hexin Bio-pharmaceutical Co., Ltd.;Zeng Chunling;Liu Xirong;Jin Zhizhong;Meng Hao CN112079773, 2020, A Location in patent:Paragraph 0089-0134

84689-36-1 Synthesis