ChemicalBook CAS DataBase List 2-PHENYLETHYL-1-BORONIC ACID PINACOL ESTER

2-PHENYLETHYL-1-BORONIC ACID PINACOL ESTER synthesis

14synthesis methods

Product Name:2-PHENYLETHYL-1-BORONIC ACID PINACOL ESTER
CAS Number:165904-22-3
Molecular formula:C14H21BO2
Molecular Weight:232.13

103-63-9 Synthesis

103-63-9
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25015-63-8
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2-PHENYLETHYL-1-BORONIC ACID PINACOL ESTER

165904-22-3
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Yield: 80%

Reaction Conditions:

Stage #1:4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane with bis(cyclopentadienyl)titanium dichloride;lithium methanolate in tert-butyl methyl ether for 0.5 h;
Stage #2:1-phenyl-2-bromoethane in tert-butyl methyl ether at 60; under 760.051 Torr; for 24 h;Inert atmosphere;

Steps:

52 Example 52
bis(cyclopentadiene) titanium dichloride (denoted as Cp2TiCl2, 0.01 mmol, 2.5 mg), lithium methoxide (denoted as MeOLi, 0.2 mmol, 7.6 mg), methyl tert-butyl ether (1 mL) Hopinacol borane (denoted as HBpin, 0.4mmol,58μL) was added to the 38mL pressure tube in sequence, stirred for 30min, and then 1-bromophenylethane (denoted as 1m, 0.2mmol, 27.3μL) was added in nitrogen (1atm ) Stir at 60°C for 24h under an atmosphere, and purify by column chromatography with petroleum ether/ethyl acetate (40:1, v/v) as the eluent to obtain the structure compound represented by formula 2m (colorless transparent liquid, 2-(2) -Phenylethyl) borate pinacol ester). The isolated yield is 80%.

References:

CN112645971, 2021, A Location in patent:Paragraph 0145-0147

103-63-9 Synthesis

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