((3,4-DIMETHOXYPHENYL)METHYLENE)METHANE-1,1-DICARBONITRILE synthesis
- Product Name:((3,4-DIMETHOXYPHENYL)METHYLENE)METHANE-1,1-DICARBONITRILE
- CAS Number:2972-80-7
- Molecular formula:C12H10N2O2
- Molecular Weight:214.22
Yield:2972-80-7 100%
Reaction Conditions:
with polymer supported poly(propylene imine)dendrimer in ethanol at 20; for 0.0833333 h;Green chemistry;Knoevenagel Condensation;
Steps:
General Procedure of Catalysis
General procedure: Aldehyde (5 mmol), active methylene compound (5 mmol), polymer-supported catalyst (25 mg, 0.5 mol-% of the substrates) and absolute ethanol (5 mL) were mixed in around bottom flask and stirred at room temperature. Progress of the reaction was monitored by TLC on silica plate using Hexane-EtOAc (10:1) as eluent. After completion of the reaction, the reaction mixture was filtered using a filter paper and the catalyst collected in the filter paper was washed several times with ethanol. The washings and filtrate were combined and evaporated under reduced pressure to isolate the product. In general the product was obtained in high purity and no further purification was required. All the products were previously reported and were characterized by melting point determination FTIR spectra and 1HNMR spectra.
References:
Gopalakrishna Panicker, Rajesh Krishnan;Krishnapillai, Sreekumar [Tetrahedron Letters,2014,vol. 55,# 15,p. 2352 - 2354] Location in patent:supporting information
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