2H-1,4-Benzoxazin-7-amine, 3,4-dihydro-4-methyl- synthesis
- Product Name:2H-1,4-Benzoxazin-7-amine, 3,4-dihydro-4-methyl-
- CAS Number:220844-82-6
- Molecular formula:C9H12N2O
- Molecular Weight:164.2
120711-93-5
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220844-82-6
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Yield:220844-82-6 88%
Reaction Conditions:
with palladium 10% on activated carbon;hydrogen in ethyl acetate at 25; for 2 h;
Steps:
30
A solution of 30-1 (0.530 g, 2.73 mmol) in ethyl acetate (40 mL) was degassed with nitrogen three times then Pd/C (0.053 g, 10% purity on charcoal, wet) was added. The reaction mixture was degassed and purged with hydrogen three times. The mixture was stirred at 25°C for 2 hours under a hydrogen atmosphere (15 psi) then diluted with ethyl acetate (100 mL), filtered, and the filtrate was concentrated under reduced pressure to afford 4-methyl-3, 4-dihydro-2H -benzo[b][1,4]oxazin-7-amine (30-2) (0.430 g, 88.0% yield) as a black brown oil.
References:
WO2022/150574,2022,A1 Location in patent:Page/Page column 181
141068-81-7
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220844-82-6
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120711-81-1
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220844-82-6
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81721-86-0
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$16.00/500mg
220844-82-6
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5735-53-5
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220844-82-6
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