3-(2-ETHOXYPHENYL)PROPIONIC ACID synthesis
- Product Name:3-(2-ETHOXYPHENYL)PROPIONIC ACID
- CAS Number:220285-28-9
- Molecular formula:C11H14O3
- Molecular Weight:194.23
1329812-54-5
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220285-28-9
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Yield:220285-28-9 67%
Reaction Conditions:
with potassium hydroxide in methanol at 60; for 16 h;Inert atmosphere;
Steps:
3-(2-Ethoxyphenyl)propionic acid (S18a)
A solution of methyl 3-(2-ethoxyphenyl)propionate (210 mg, 1.01 mmol) in methanolic KOH (1.0 M, 5.0 mL, 5.0 mmol) was heated at 60 °C for 16 h. The solvent was removed and the residue was diluted with water and acidified (pH 3) with 10% aqueous HCl to obtain a precipitate. The precipitate was collected, washed with water, and dried to yield 150 mg (76%) of product as a white powder.
References:
Williams, John D.;Khan, Atiyya R.;Cardinale, Steven C.;Butler, Michelle M.;Bowlin, Terry L.;Peet, Norton P. [Bioorganic and Medicinal Chemistry,2014,vol. 22,# 1,p. 419 - 434] Location in patent:supporting information
6236-69-7
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220285-28-9
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20349-89-7
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220285-28-9
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90-02-8
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220285-28-9
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