3,3,3-Trifluoro-2,2-dimethylpropionic acid synthesis
- Product Name:3,3,3-Trifluoro-2,2-dimethylpropionic acid
- CAS Number:889940-13-0
- Molecular formula:C5H7F3O2
- Molecular Weight:156.1
1260505-00-7
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889940-13-0
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Yield:889940-13-0 84.3%
Reaction Conditions:
with sodium hydroxide in water at 90 - 100;
Steps:
c Step c, to obtain the target product:
Prepare a dry, clean 1L four-necked flask. 18g of intermediate 2 was added to it, 500 ml of a 5 mol/L sodium hydroxide aqueous solution was placed in the flask, Stir well, The mixture was heated to a temperature of 90-100 ° C and refluxed overnight. The reaction was terminated until the intermediate 2 was completely reacted. Concentrated hydrochloric acid was used to adjust the pH to 1. Continue stirring for 30 minutes, Extracted with 50*3ml of dichloromethane, The organic layers were combined and concentrated to give a white solid. The yield was 84.3% (GC 98%).
References:
Haimen Ruiyi Pharmaceutical Technology Co., Ltd.;Xue Song CN109180459, 2019, A Location in patent:Paragraph 0012
188726-21-8
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889940-13-0
153 suppliers
$25.00/250mg