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3-(3-METHOXY-PHENYL)-2-METHYL-PROPIONIC ACID synthesis

3synthesis methods
802294-64-0 Synthesis
Propionic-2,3-14C1 acid (8CI)

802294-64-0
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Yield:61227-51-8 86 %

Reaction Conditions:

Stage #1: propionic acidwith n-butyllithium;diisopropylamine in tetrahydrofuran at -78 - 40;Inert atmosphere;
Stage #2: m-methoxybenzyl chloride in tetrahydrofuran at 0 - 20;

References:

Dong, Zi-Yu;Zhao, Jia-Hui;Wang, Peng;Yu, Jin-Quan [Organic Letters,2022,vol. 24,# 42,p. 7732 - 7736] Location in patent:supporting information