ChemicalBook CAS DataBase List 3,4-Difluorophenol

3,4-Difluorophenol synthesis

5synthesis methods

Product Name:3,4-Difluorophenol
CAS Number:2713-33-9
Molecular formula:C6H4F2O
Molecular Weight:130.09

3,4-Difluorophenol is mainly used as a liquid crystal material intermediate, mainly used in laboratory research and development process. It can be synthesized by reduction reaction of 3,4-Difluorobenzaldehyde.

168267-41-2
326 suppliers
$14.00/5g

2713-33-9
301 suppliers
$9.00/5g

Yield:2713-33-9 92%

Reaction Conditions:

with dihydrogen peroxide in water at 20; for 0.0833333 h;

Steps:

General procedure for ipso-hydroxylation of arylboronic acids
General procedure: A mixture of arylboronic acid (0.5 mmol), 10 mg cellulose (15 wt%) and 2 mL distilled H₂O were taken in an oven dried 10 mL round bottomed flask. To this 30% aq H₂O₂ (0.5 mL) was added dropwise and stirred at room temperature for 5 min. After completion of the reaction (monitored by TLC), aqueous layer was centrifuged to recover the catalyst for further use. The products were extracted with EtOAc (3x10 mL), dried with anhydrous Na₂SO₄ and then vacuum dried. The crude product was purified by column chromatography on silica gel (EtOAc/ hexane) to obtain the desired product.

References:

Laskar, Khairujjaman;Paul, Subham;Bora, Utpal [Tetrahedron Letters,2019,vol. 60,# 38,art. no. 151044]

FullText

369-34-6 Synthesis

369-34-6
408 suppliers
$5.00/5g

2713-33-9
301 suppliers
$9.00/5g

References

34036-07-2
356 suppliers
$7.00/5g

2713-33-9
301 suppliers
$9.00/5g

References

3863-11-4 Synthesis

3863-11-4
329 suppliers
$10.00/25 g

2713-33-9
301 suppliers
$9.00/5g

References

367-11-3
306 suppliers
$10.00/1g

2713-33-9
301 suppliers
$9.00/5g

References

3,4-Difluorophenol Related Search:

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