3,6-Dichloro-4-methylpyridazine synthesis
- Product Name:3,6-Dichloro-4-methylpyridazine
- CAS Number:19064-64-3
- Molecular formula:C5H4Cl2N2
- Molecular Weight:163
5754-18-7
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$14.00/1g
19064-64-3
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Yield:19064-64-3 89%
Reaction Conditions:
in trichlorophosphate
Steps:
1 4-methyl-3,6-dichloropyridazine
4-methyl-3,6-dichloropyridazine
A solution of 4-methyl-3,6-pyridazinediol (252 g, 2 mol) in phosphorous oxychloride (2000 ml) is refluxed on an oil bath for 7 h.
The excess amount of POCl3 is removed in vacuum, the residue is cooled and added to 5 kg of ice.
The reaction mixture is then neutralized with aqueous ammonia and extracted with chloroform (8x500 ml).
The combined organic extract is washed with brine (4x500 ml), dried over MgSO4 and the solvent is removed in vacuum, yielding the desired product (290 g, 89%).
References:
Obshchestvo S Ogranichennoy Otvetstvennostyou "Fusion Pharma";CHILOV, Germes Grigorievich;TITOV, Ilya Yurievich EP2743266, 2014, A2 Location in patent:Page/Page column
5754-18-7
167 suppliers
$14.00/1g
19064-64-3
247 suppliers
$6.00/5g
117122-49-3
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19064-64-3
247 suppliers
$6.00/5g
616-02-4
243 suppliers
$7.00/5g
19064-64-3
247 suppliers
$6.00/5g