3-BROMO-4-CHLOROBENZONITRILE synthesis
- Product Name:3-BROMO-4-CHLOROBENZONITRILE
- CAS Number:948549-53-9
- Molecular formula:C7H3BrClN
- Molecular Weight:216.46
623-03-0
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Yield:948549-53-9 70%
Reaction Conditions:
with potassium bromate;sulfuric acid at 20; for 7 h;
Steps:
1.1 Preparation of 3-bromo-4-chlorobenzonitrile
Add 4-chlorobenzonitrile 5g (3.63mmol) into 100mL 70% sulfuric acid, stirring, slowly add potassium bromate 6.5g (5.98mmol), after 3 hours adding, the reaction at room temperature again 4 hours stirred, filtering, drying to obtain white solid 5.5g, GC tested content 98%, yield 70%.
References:
Nanjing Huawe Medicine Technology Development co., LTD;Zhang, Xiaoqing;Song, Zhichun;Bao, Jinyuan;Jiang, Yuwei CN103524456, 2016, B Location in patent:Paragraph 0053; 0055; 0057-0059
