ChemicalBook CAS DataBase List 3-ETHYL-3-(3-HYDROXYPHENYL)-1-METHYLAZEPAN-2-ONE

3-ETHYL-3-(3-HYDROXYPHENYL)-1-METHYLAZEPAN-2-ONE synthesis

8synthesis methods

Product Name:3-ETHYL-3-(3-HYDROXYPHENYL)-1-METHYLAZEPAN-2-ONE
CAS Number:71556-74-6
Molecular formula:C15H21NO2
Molecular Weight:247.33

3-ethylhexahydro-3-(3-methoxyphenyl)-1-methyl-2H-azepin-2-one

71556-72-4
3 suppliers
inquiry

3-ETHYL-3-(3-HYDROXYPHENYL)-1-METHYLAZEPAN-2-ONE

71556-74-6
37 suppliers
$109.56/1gm:

Yield:71556-74-6 81.4%

Reaction Conditions:

with boron tribromide in dichloromethane at 0; for 3.5 h;

Steps:

3 Embodiment 3: preparation of compoundIII:

The 0.5g compound II dissolved in 15 ml anhydrous DCM (dichloromethane), will 1.44g boron tribromide soluble in 4mLDCM (dichloromethane) is applied to the above-mentioned reaction solution. Cooling to 0 °C reaction 3.5h rear, using saturated NaHCO₃solution to adjust pH to 5-6, separating, the aqueous phase used 10mLDCM extraction, combined with the phase, using anhydrous NaSO₄drying, was eventually 0.385g white solid (yield 81.4%).

References:

CN105801483,2016,A Location in patent:Paragraph 0025; 0030; 0031