ChemicalBook CAS DataBase List 3'-METHOXY-BIPHENYL-4-YLAMINE HYDROCHLORIDE

3'-METHOXY-BIPHENYL-4-YLAMINE HYDROCHLORIDE synthesis

6synthesis methods

Product Name:3'-METHOXY-BIPHENYL-4-YLAMINE HYDROCHLORIDE
CAS Number:207287-79-4
Molecular formula:C13H13NO
Molecular Weight:199.25

10365-98-7 Synthesis

10365-98-7
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$9.00/10g

540-37-4
436 suppliers
$6.00/5g

3'-METHOXY-BIPHENYL-4-YLAMINE HYDROCHLORIDE

207287-79-4
58 suppliers
$40.00/1g

Yield: 100%

Reaction Conditions:

with potassium carbonate in ethanol at 80; for 36 h;Inert atmosphere;Suzuki-Miyaura Coupling;

Steps:

4-Amino-3'-methoxybiphenyl (6mb)
General procedure: PICB-NHC-Pd catalyst (3) (0.000625 mmol, 0.25 mol% as Pd), K2CO3 (0.25 mmol, 1 eq.), boronic acid (0.3 mmol, 1.2eq.) and substrate (if it is solid, 0.25mmol, 1 eq.) were placed in reaction tube then heated and dried with dryer in vacuo for2~5 min. After Ar substitution with Ar balloon, substrate (if it is liquid, 0.25 mmol, 1 eq.) and EtOH were added. Reactionmixture was stirred at 80 C for 36 hours. Catalyst was seperated by filtration and washed with DCM (20 mL) and water.Aqueous NH4Cl solution (sat, 20 mL) was added and the aqueous layer was extracted with DCM (3 x 20 mL). Thecombined organic layers were dried over MgSO4 and the solvent was removed in vacuo. The residue was purified bypreparative TLC

References:

Min, Hyemin;Miyamura, Hiroyuki;Kobayashi, Shu [Chemistry Letters,2016,vol. 45,# 7,p. 837 - 839] Location in patent:supporting information

10365-98-7 Synthesis

10365-98-7
403 suppliers
$9.00/10g

106-40-1 Synthesis