3-methyl-5-nitrobenzene-1,2-diol synthesis
- Product Name:3-methyl-5-nitrobenzene-1,2-diol
- CAS Number:5378-76-7
- Molecular formula:C7H7NO4
- Molecular Weight:169.13
488-17-5
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Yield:5378-76-7 14.68%
Reaction Conditions:
with tert.-butylnitrite in tetrahydrofuran;water; for 1 h;
Steps:
12.A Step A
At 20 °C, to a solution of the compound 12-1 (5 g, 40.28 mmol, 1 eq) in tetrahydrofuran (200 mL) were added tert-butyl nitrite (8.31 g, 80.56 mmol, 2 eq) and water (725.62 mg, 40.28 mmol, 1 eq), and the reaction system was stirred for 1 hour. The reaction solution was concentrated under reduced pressure to obtain a residue, and the residue was separated and purified by column chromatography (V/V) (PE : EA= 6 : 1) to obtain compound 12-a (1 g, yield: 14.68%).
References:
EP3766883,2021,A1 Location in patent:Paragraph 0149
534-52-1
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