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ChemicalBook CAS DataBase List 3-OCTANOL

3-OCTANOL synthesis

11synthesis methods
Can be prepared in the racemic form by reduction of ethyl-n-amyl ketone with sodium in ether solution.
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Yield:589-98-0 76 %Spectr.

Reaction Conditions:

with hydrazine hydrate in acetonitrile at 21 - 25; for 72 h;

Steps:

Typical procedure for aerobic reduction of olefins catalyzed by 1a
General procedure: A mixture of an olefin (0.25 mmol), hydrazine monohydrate (36 mL, 0.75 mmol), 1a (20 mg, 5 mmol), and acetonitrile (2.0 mL) was stirred (700 rpm) at room temperature (21-25 °C) under air. The reaction was monitored by either GC analysis with the corrected area normalization method or 1H NMR measurement using 1,3,5-trimethoxybenzene as an internal standard. Analytical data for 4a-4f were in agreement with the published data.2

References:

Arakawa, Yukihiro;Sato, Fumiaki;Ariki, Kenta;Minagawa, Keiji;Imada, Yasushi [Tetrahedron Letters,2020,vol. 61,# 14,art. no. 151710] Location in patent:supporting information

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