3-PHENOXYPYRROLIDINE HYDROCHLORIDE synthesis

Yield:21767-15-7 100%

Reaction Conditions:

with hydrogenchloride in 1,4-dioxane;dichloromethane at 20;Cooling;

Steps:

10.3

Step 3: 3-Phenoxypyrrolidine hydrochlorideTo a cooled solution of tart-butyl 3-phenoxypyrrolidine-l-carboxylate (172 mg, 0.65 mmol; which may be prepared as described in Step 2) in dichloromethane (4.3 ml_) was added dropwise HCI 4N in dioxane (3.2 ml_). The solution was warmed to room temperature and stirred for 1 h. The solvent was evaporated under reduced pressure to give the title compound (135 mg, quantitative) as an orange oil .*H NMR (DMSO-c/e, 300 MHz) : δ (ppm) : 9.77-9.58 (m, 1H), 9.57-9.38 (m, 1H), 7.37-7.26 (m, 2H), 7.03-6.90 (m, 3H), 5.18-5.09 (m, 1H), 3.59-3.07 (m, 4H), 2.27-2.03 (m, 2H).

References:

WO2011/61214,2011,A1 Location in patent:Page/Page column 48